Actively Recruiting

Phase Not Applicable
Age: 65Years +
All Genders
NCT06768580

Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty

Led by Tanta University · Updated on 2025-04-15

135

Participants Needed

1

Research Sites

89 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The aim of this study is to assess the effect of oral melatonin versus intraoperative lidocaine infusion on incidence of postoperative delirium in elderly patients undergoing total hip arthroplasty under spinal anesthesia.

CONDITIONS

Official Title

Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty

Who Can Participate

Age: 65Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Elderly patients aged >65 years old undergoing unilateral total hip arthroplasty.
  • Patients with body mass index (BMI) (18-30) kg/m2.
  • American Society of Anesthesiologists (ASA) physical status I-III, scheduled to undergo unilateral total hip arthroplasty.
Not Eligible

You will not qualify if you...

  • History of mental illness or scoring less than 8 using abbreviated mental test (AMT) before operation.
  • Obvious sinus bradycardia (heart rate of <50 beats per minute) or other serious cardiovascular diseases.
  • Symptomatic cerebrovascular disease (such as previous stroke).
  • History of liver and kidney dysfunction.
  • Allergy to lidocaine or melatonin.
  • Metabolic disorders and fluid, electrolytes disturbances.
  • Alcohol dependence or drug abuse.
  • Redo surgery or infectious complications.
  • CNS medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).
  • History of deep vein thrombosis.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Tanta University

Tanta, El-Gharbia, Egypt, 31527

Actively Recruiting

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Research Team

A

Alshaimaa S Alasrag, Master

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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