Actively Recruiting
The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis Evaluated in Multiple Methods
Led by Capital Medical University · Updated on 2026-03-05
60
Participants Needed
2
Research Sites
28 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
High frequency chest wall oscillation (HFCWO) is currently one of the most common and widespread mechanical airway clearance techniques (ACTs) in clinical practice in China. As an external airway oscillation technique, it has been proven in previous clinical practices that it can help clear secretions by vibrating the chest wall, loosening the secretions adhering to the airway walls and promoting ciliary movement, thereby improving lung ventilation and re-expansion. However, there are still some groups of patients for whom this technique is not suitable in clinical practice, such as those who are uncomfortable with the oscillation, have damaged skin on the chest and back, have unstable rib fractures, or have poorly positioned tracheostomy tubes. In recent years, integrating multiple techniques into a single treatment has become a trend. Among them, oscillation and lung expansion (OLE) combines continuous positive airway pressure (CPAP), continuous high-frequency oscillation (CHFO), and nebulization, which can effectively clear airway secretions and promote lung re-expansion. Currently, only a few studies have confirmed that OLE has a positive impact on improving respiratory function in patients with acute respiratory failure, severe burns, and after lung surgery. This study aims to further compare the effects of the above two mechanical ACTs on improving lung ventilation and re-expansion by electrical impedance tomography (EIT), and optimize the clinical practice of physical therapists.
CONDITIONS
Official Title
The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis Evaluated in Multiple Methods
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- High mucus secretion in the airway with pulmonary infection, including coughing up large amounts of white sticky, yellow, or yellow purulent phlegm
- Phlegm sounds can be heard in the lungs
- Frequency of sputum aspiration is higher than once every 4 hours
- Tracheotomy time of 7 days or more
- Vital signs are stable
You will not qualify if you...
- Hemodynamic instability
- Inhaled oxygen concentration (FiO2) greater than 60%
- Untreated pneumothorax
- Patients who have undergone total pneumonectomy
- Hemoptysis
- Presence of pulmonary bullae
- Patients with delirium and restlessness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Respiratory rehabilitation center
Beijing, Beijing Municipality, China, 100144
Actively Recruiting
2
Shuo Chen
Beijing, China
Completed
Research Team
S
Shuo Chen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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