Actively Recruiting
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Led by Margaux M. Salas, PhD · Updated on 2025-02-25
30
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants. Participants will be randomized to (1) a moderate dose ketamine, (2) moderate dose ketamine +Mg, or (3) a magnesium control group. Participants will complete self-reported pain and PTSD questionnaires throughout the \~24-week study period. The outlined strategy will provide evidence for the utility of ketamine in neuropathic pain management and pain associated comorbidities within a military population.
CONDITIONS
Official Title
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years
- Diagnosed with chronic neuropathic pain lasting 3 months or more
- Biologic male or biologic female
- Women of childbearing age must have no plans for pregnancy during the study, use contraception, and agree to pregnancy tests
- Active duty military, veterans, retirees, or military dependents
- No ketamine treatment in the past year
- Moderate neuropathic pain scale rating between 4 and 7
You will not qualify if you...
- Cognitive dysfunction
- Psychiatric illness involving psychosis
- Neurocognitive disorder
- History of traumatic brain injury
- Acute cardiovascular disease or poorly controlled hypertension
- Untreated or uncontrolled thyroid disease including hyperthyroidism
- Severe liver or kidney disease or renal impairment
- Recent heart attack, vascular disease, or other medical conditions contraindicating ketamine
- Active substance abuse or risk of substance use
- Pregnant, lactating, or planning pregnancy within 12 weeks after treatment
- Elevated blood pressure or hypertension
- Known allergy to ketamine
- Hemodynamic instability or respiratory depression
- Use of Theophylline, Aminophylline, sympathomimetics, vasopressin, or benzodiazepines
- History of drug abuse or dependence
- Inability to follow treatment protocols including food intake, medication restrictions, clinic observation, or post-treatment transportation arrangements
AI-Screening
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Trial Site Locations
Total: 1 location
1
Brooke Army Medical Center
San Antonio, Texas, United States, 78234
Actively Recruiting
Research Team
M
Margaux M Salas, PhD
CONTACT
K
Kevin C Peterson, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
3
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