Actively Recruiting
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
Led by Seoul National University Bundang Hospital · Updated on 2026-04-20
360
Participants Needed
1
Research Sites
49 weeks
Total Duration
On this page
Sponsors
S
Seoul National University Bundang Hospital
Lead Sponsor
V
Vantive Health LLC
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.
CONDITIONS
Official Title
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 years or older
- Admitted to the ICU with septic shock (Sepsis-3 criteria) between March 2021 and August 2025
- Required Continuous Renal Replacement Therapy (CRRT) due to acute kidney injury (AKI)
You will not qualify if you...
- Death or withdrawal of life-sustaining therapy within 48 hours of ICU admission
- Patients with End-Stage Renal Disease (ESRD)
- Patients with missing critical covariates
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
Research Team
S
Sung Yoon Lim, MD. PhD
CONTACT
M
Myung Jin Song, MD.PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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