Actively Recruiting
The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study
Led by University of Nottingham · Updated on 2025-06-22
30
Participants Needed
1
Research Sites
59 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study involves the intake of Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), to test their effects on systematic inflammation in the body and gut microbiome composition. Study subjects will be healthy elderly with early signs of frailty or pre-frailty from the local population and will be asked to attend the laboratory on 2 occasions; before and after 4-week' supplementing the diet daily with either 10g of pectin with 10g of whey protein and 10g of cocoa powder added as flavour (active arm) or 10g of whey protein with 10g of cocoa powder added as flavour (placebo). Participants will be given the blinded products portioned in individual sachets, with instructions to add the contents of one sachet a day to 150ml of milk and to consume immediately. At each study visit (\~90 minutes), participants will be asked to provide a stool and blood sample, will have blood pressure, heart rate, weight, height, and waist/hip ratio measured, research team will perform physical functioning test (Time up and go test, 30-second sit to stand test) as well as participants will complete the quality-of-life questionnaire (SF-36), the Depression and Anxiety (HADS) and the Gastrointestinal Symptom Rating Scale (GSRS).
CONDITIONS
Official Title
The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent for participation in the study
- Aged over 65 years
- Body mass index (BMI) between 18.5 and 39.9 kg/m2
- Considered pre-frail or frail based on the Simple Frailty Questionnaire (FRAIL)
You will not qualify if you...
- Gastrointestinal conditions such as IBS, IBD, coeliac disease, gastroparesis, or food intolerances
- History of major surgery limiting study participation or completion
- History of gastrointestinal resection surgery, including bariatric surgery
- Use of antibiotics, antifungal medications, probiotics, or prebiotics within 90 days before the study
- Taking immunosuppressants, amiodarone, or perhexiline
- Currently following or planning to start a specialized commercial weight loss diet or program
- History of side effects to probiotics or prebiotics
- History or current psychiatric illness
- History or current neurological condition, such as epilepsy
- Participation in another research study involving invasive procedures or inconvenience allowance in the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Nottingham
Nottingham, Nottingham, United Kingdom, NG7 2UH
Actively Recruiting
Research Team
N
Noor K Al-Tameemi, PhD student candidate
CONTACT
P
Professor Ana Valdes
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here