Study of Pentoxifylline Medication Effects on Endometrial Thickness and Outcomes in Frozen Embryo Transfer for Women Undergoing IVF

What this Trial Is About

Researchers are evaluating the effect of different vasodilators, specifically pentoxifylline, in women with unexplained infertility who are undergoing in vitro fertilization IVF using frozen embryo transfer. This prospective randomized clinical study includes women aged 18 to 43 years with good quality day five frozen embryos. The study was approved by the Ethical Committee of Beni Suef University Hospitals in Egypt, and informed consent was obtained from participants. Participants are randomly assigned into two groups. The control group receives estradiol valerate 2 mg tablets starting at one pill three times daily, which may be increased based on endometrial thickness measured by vaginal ultrasound on day 9. The experimental group receives pentoxifylline 400 mg once daily in addition to the estradiol valerate treatment, starting from the first day of the cycle until the day progesterone treatment begins. During the study, all participants undergo thorough history taking, physical examination, and laboratory tests including hormone levels AMH, FSH, LH, estradiol, prolactin, TSH, as well as ultrasonography to assess endometrial thickness. The primary outcome measured is pregnancy status at one month. The total participation duration varies according to the treatment cycle and monitoring schedule, with ongoing assessments to evaluate treatment effects on embryo transfer outcomes.

Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer Outcomes