Actively Recruiting
Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis
Led by Egas Moniz - Cooperativa de Ensino Superior, CRL · Updated on 2025-07-17
20
Participants Needed
2
Research Sites
33 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens. This therapeutic approach has been explored in a variety of medical fields due to its versatility and minimal invasiveness. In the context of periodontal diseases, PDT has emerged as a promising adjunctive treatment in the non-surgical management of periodontitis. Periodontitis, a chronic inflammatory disease caused by the accumulation of pathogenic bacteria in the subgingival environment, is often treated with mechanical debridement, including scaling and root planing (SRP). However, these conventional methods may not always achieve complete bacterial eradication. PDT, when used in conjunction with SRP, has the potential to significantly enhance bacterial elimination. The use of photosensitizers, activated by specific wavelengths of light, leads to the generation of singlet oxygen, which can effectively kill a broad spectrum of periodontal pathogens, including those resistant to antibiotics. As an adjunctive therapy, PDT can improve the clinical outcomes of non-surgical periodontitis treatment by reducing bacterial load, promoting tissue healing, and potentially decreasing the need for more invasive procedures. The ability of PDT to target bacteria without harming surrounding tissues makes it an attractive option for patients who require a non-invasive treatment approach. In conclusion, photodynamic therapy is a valuable addition to periodontal treatment regimens, offering enhanced bacterial reduction and improved therapeutic outcomes in the management of periodontitis.
CONDITIONS
Official Title
Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older with periodontitis diagnosed according to EFP/APA 2018 criteria
- At least 10 teeth present in the mouth
You will not qualify if you...
- Periodontal treatment in the previous six months
- Use of antibiotics, NSAIDs, or immunosuppressants in the previous six months
- Acute oral infection
- Pregnant or breastfeeding women
- Teeth with grade III mobility
- Pockets with probing depth greater than 10 mm
- Use of antimicrobial mouthwash in the previous two months
- Patients with diabetes mellitus
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Egas Moniz School of Health and Science
Almada, Monte Da Caparica, Portugal, 2825-084
Actively Recruiting
2
Egas Moniz School of Health and Science
Almada, Monte Da Caparica, Portugal, 2829-511
Active, Not Recruiting
Research Team
F
Filipa Sousa, Master
CONTACT
I
Inês Dra. Gomes, phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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