Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07070453

Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Led by Egas Moniz - Cooperativa de Ensino Superior, CRL · Updated on 2025-07-17

20

Participants Needed

2

Research Sites

33 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens. This therapeutic approach has been explored in a variety of medical fields due to its versatility and minimal invasiveness. In the context of periodontal diseases, PDT has emerged as a promising adjunctive treatment in the non-surgical management of periodontitis. Periodontitis, a chronic inflammatory disease caused by the accumulation of pathogenic bacteria in the subgingival environment, is often treated with mechanical debridement, including scaling and root planing (SRP). However, these conventional methods may not always achieve complete bacterial eradication. PDT, when used in conjunction with SRP, has the potential to significantly enhance bacterial elimination. The use of photosensitizers, activated by specific wavelengths of light, leads to the generation of singlet oxygen, which can effectively kill a broad spectrum of periodontal pathogens, including those resistant to antibiotics. As an adjunctive therapy, PDT can improve the clinical outcomes of non-surgical periodontitis treatment by reducing bacterial load, promoting tissue healing, and potentially decreasing the need for more invasive procedures. The ability of PDT to target bacteria without harming surrounding tissues makes it an attractive option for patients who require a non-invasive treatment approach. In conclusion, photodynamic therapy is a valuable addition to periodontal treatment regimens, offering enhanced bacterial reduction and improved therapeutic outcomes in the management of periodontitis.

CONDITIONS

Official Title

Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 18 years or older with periodontitis diagnosed according to EFP/APA 2018 criteria
  • At least 10 teeth present in the mouth
Not Eligible

You will not qualify if you...

  • Periodontal treatment in the previous six months
  • Use of antibiotics, NSAIDs, or immunosuppressants in the previous six months
  • Acute oral infection
  • Pregnant or breastfeeding women
  • Teeth with grade III mobility
  • Pockets with probing depth greater than 10 mm
  • Use of antimicrobial mouthwash in the previous two months
  • Patients with diabetes mellitus

AI-Screening

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Trial Site Locations

Total: 2 locations

1

Egas Moniz School of Health and Science

Almada, Monte Da Caparica, Portugal, 2825-084

Actively Recruiting

2

Egas Moniz School of Health and Science

Almada, Monte Da Caparica, Portugal, 2829-511

Active, Not Recruiting

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Research Team

F

Filipa Sousa, Master

CONTACT

I

Inês Dra. Gomes, phd

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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