Actively Recruiting
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Led by Lund University · Updated on 2025-05-30
200
Participants Needed
1
Research Sites
308 weeks
Total Duration
On this page
Sponsors
L
Lund University
Lead Sponsor
R
Region Skane
Collaborating Sponsor
AI-Summary
What this Trial Is About
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patients with POTS experience several debilitating symptoms including light-headedness, nausea, blurred vision, fatigue, mental confusion ("brain-fog"), chest pain and gastrointestinal problems. Several potential underlying mechanisms have been suggested for POTS including autonomic denervation, hypovolemia, hyperadrenergic stimulation and autoantibodies against adrenergic receptors. However, none of these proposed mechanisms has yet led to an effective treatment. Physical activity is recommended as a complimentary treatment in POTS in international guidelines. However, less is known regarding how physical activity could successfully be implemented in clinical practice in patients with POTS. Thus, in the current study, we aim to assess the effect of a 16-week specialized physical activity program in POTS.
CONDITIONS
Official Title
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with POTS who have given written informed consent for participation in the study.
You will not qualify if you...
- Patients with myalgic encephalomyelitis are excluded from the study.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Skånes Universitetssjukhus Malmö, Department of Cardiology
Malmö, Sweden, 214 28
Actively Recruiting
Research Team
I
Isabella Kharraziha, MD
CONTACT
V
Viktor Hamrefors, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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