Actively Recruiting
Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
Led by Pennington Biomedical Research Center · Updated on 2025-12-04
8
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.
CONDITIONS
Official Title
Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mini Mental State Examination (MMSE) score < 25
You will not qualify if you...
- Taking daily medication specifically for anxiety, including benzodiazepines
- Infant, child, or teenager
- Pregnant woman
- Prisoner
- Having any condition that impedes testing of the study hypothesis or deemed unsuitable by the investigative team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70806
Actively Recruiting
Research Team
T
Tim Gilbert, M.D.
CONTACT
C
Candida Rebello, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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