Actively Recruiting
Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition
Led by Pennington Biomedical Research Center · Updated on 2025-12-04
8
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying whether weekly insulin delivered in short intervals lasting up to two hours can improve how adults with Alzheimer's Disease use glucose and their cognitive function. The study also aims to understand the safety and practicality of this insulin intervention. Key questions include whether insulin sensitivity and cognition improve, and what changes occur in brain glucose uptake. Participants will receive insulin infusions every five minutes for about two hours once a week over six months. The infusion frequency may decrease based on participants' responses. The intervention is designed to mimic physiological insulin delivery. Cognitive function will be assessed using tools like the Montreal Cognitive Assessment and the Revised Memory and Behavior Problems Checklist. During the study, participants will undergo cognitive testing and monitoring for any adverse effects throughout the six-month period. Brain glucose uptake will also be measured. This study involves regular visits for infusions and assessments to evaluate changes in insulin sensitivity and cognition over time.
CONDITIONS
Brief Title
Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mini Mental State Examination (MMSE) score less than 25
You will not qualify if you...
- Taking daily medication for anxiety including benzodiazepines
- Being an infant, child, or teenager
- Being pregnant
- Being a prisoner
- Having any condition that impedes testing of the study hypothesis or deemed unsuitable by the investigative team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants receive insulin infusion every five minutes over approximately two hours initially weekly, with frequency reducing based on response, for a total of six months.
Weekly visits initially with reducing frequency based on participant response
Trial Site Locations
Total: 1 location
1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70806
Actively Recruiting
Research Team
T
Tim Gilbert, M.D.
C
Candida Rebello, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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