Studying Weekly Insulin Treatment to Improve Insulin Use and Thinking Skills in Adults with Alzheimers Disease

What this Trial Is About

Researchers are studying whether weekly insulin delivered in short intervals lasting up to two hours can improve how adults with Alzheimers Disease use glucose and their cognitive function. The study also aims to understand the safety and practicality of this insulin intervention. Key questions include whether insulin sensitivity and cognition improve, and what changes occur in brain glucose uptake. Participants will receive insulin infusions every five minutes for about two hours once a week over six months. The infusion frequency may decrease based on participants responses. The intervention is designed to mimic physiological insulin delivery. Cognitive function will be assessed using tools like the Montreal Cognitive Assessment and the Revised Memory and Behavior Problems Checklist. During the study, participants will undergo cognitive testing and monitoring for any adverse effects throughout the six-month period. Brain glucose uptake will also be measured. This study involves regular visits for infusions and assessments to evaluate changes in insulin sensitivity and cognition over time.

Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition