Actively Recruiting
Effect of Position and Anesthetic Choice on Intraocular Pressure in Robotic Gynecologic Oncology Patients
Led by University of Florida · Updated on 2026-01-16
40
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how different anesthetic methods affect intraocular pressure (IOP) in female patients undergoing robotic surgery for gynecologic cancer. The study focuses on comparing total intravenous anesthesia (TIVA) with conventional balanced anesthesia to understand their impact on the increase of IOP during surgery. This research aims to quantify changes in IOP caused by steep Trendelenburg positioning and abdominal insufflation, which are known to raise IOP during robotic procedures. Participants will be randomly assigned to receive either TIVA or balanced anesthesia. Both groups receive induction with propofol, fentanyl, and rocuronium, with lidocaine to reduce injection discomfort. The TIVA group receives intravenous infusions without inhaled anesthetics, while the balanced anesthesia group maintains anesthesia with isoflurane gas. Ventilation settings and muscle relaxation are carefully controlled during surgery to keep blood pressure and breathing parameters stable. During surgery, an anesthesiologist trained by an ophthalmologist measures IOP in both eyes at multiple time points, including after induction, during positioning, and before extubation. If IOP remains elevated, additional measurements and ophthalmology consultations may occur after surgery. The main outcome is the degree of change in IOP on the day of surgery. Participants will be monitored closely for abnormal IOP readings and receive follow-up care as needed.
CONDITIONS
Brief Title
Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18 years or older
- Written informed consent and agreement to follow study procedures
- Planning robotic surgery for gynecological cancer or high suspicion of cancer
- Cleared for surgery by the pre-anesthesia clinic
- All robotic gynecologic cancer patients 18 years or older with preexisting medical conditions deemed ready for surgery
You will not qualify if you...
- Known increased intraocular pressure or prior eye surgery within the past month
- Eye conditions preventing intraocular pressure measurement as determined by an ophthalmologist
- Previous treatment or diagnosis of increased intraocular pressure
- Eye surgery within 30 days before consent
- Ophthalmologist determination that intraocular pressure measurement is not possible
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Day of surgery
Participants receive one of two anesthesia methods during robotic gynecologic oncology surgery. Intraocular pressure is measured at multiple points throughout the surgery to assess the effect of anesthetic choice and patient positioning.
1 surgical visit with 7 intraoperative intraocular pressure measurements and 1 post-operative measurement if needed
Duration - Post-operative recovery period until discharge
If intraocular pressure remains elevated after surgery, participants receive additional monitoring in the post-anesthesia care unit and may have an ophthalmology consult for further evaluation.
1 post-operative visit in recovery area (in-person) if needed
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
S
Sonia Mehta, MD
A
Anna Woods
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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