Actively Recruiting
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Led by Beijing Chao Yang Hospital · Updated on 2023-12-20
368
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury. The investigators hypothesized that the prolonged sedation of dexmedetomidine after successful reperfusion of endovascular thrombectomy may improve the clinical outcome of acute ischemic stroke patients.
CONDITIONS
Official Title
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- NIH Stroke Scale score between 2 and 25
- Modified Rankin Scale score before stroke less than 3
- Diagnosed with acute ischemic stroke including anterior circulation
- Successful reperfusion with mTICI score 2b or 3
- Planned to receive mechanical thrombectomy under local anesthesia and sedation per 2018 AHA/ASA guidelines
- Informed consent signed by patient or legal representative
You will not qualify if you...
- Intracerebral hemorrhage in the affected vessel area in the past 6 weeks
- Prior stent treatment at the responsible vessel
- Neurological function restored at or before angiography
- Allergies or contraindications to heparin, aspirin, clopidogrel, rapamycin, lactic acid polymer, poly (n-butyl methacrylate), stainless steel, anesthetics, or contrast agents
- Hemoglobin less than 70 g/L, platelet count less than 50 x 10^9/L, irreversible INR greater than 1.5, or uncorrectable bleeding factors
- Blood glucose less than 2.7 mmol/L or greater than 22.2 mmol/L
- Severe liver or kidney dysfunction (ALT or AST more than 3 times upper limit, creatinine more than 1.5 times upper limit)
- Pregnant or breastfeeding women
- History of mental illness
- Stroke due to other acute diseases or postoperative stroke from other operations
- Heart rate less than 50 bpm, second or third degree atrioventricular block (unless pacemaker implanted), systolic blood pressure less than 90 mmHg despite two continuous vasoactive drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing ChaoYang Hospital
Beijing, Beijing Municipality, China, 100020
Actively Recruiting
Research Team
L
Lina Yang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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