What is ibuprofen and dexamethasone studying for post-endodontic pain?

This trial is studying how pre-medication with ibuprofen or dexamethasone affects pain after root canal treatment in patients with irreversible pulpitis. Researchers want to compare these anti-inflammatory drugs to understand their impact on managing post-treatment pain. The study is sponsored by the Armed Forces Institute of Dentistry, Pakistan.

Who may be eligible for this post-endodontic pain clinical trial?

Adults aged 18 to 50 years with symptomatic irreversible pulpitis and healthy systemic condition may be eligible. Both men and women can join, but patients should not be taking preoperative analgesics or antibiotics, and pregnant or breastfeeding women are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this post-endodontic pain clinical trial?

Study-related care, including the study drugs and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should be prepared for any travel-related costs.

Actively Recruiting

Phase 2

Age: 18Years - 50Years

All Genders

Healthy Volunteers

ID06980870

Study of Ibuprofen and Dexamethasone Pre-Medication to Reduce Pain After Root Canal Treatment in Adults with Inflamed Teeth

Led by Armed Forces Institute of Dentistry, Pakistan · Updated on 2025-05-20

130

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying the effect of pre-medication with anti-inflammatory drugs, specifically ibuprofen and dexamethasone, on post-endodontic pain in patients with symptomatic irreversible pulpitis. This Phase 2 randomized and double-blind trial aims to compare these two drugs in managing pain after root canal treatment. The study will include adult patients aged 18 to 50 who have acutely inflamed pulp without swelling or draining sinus and are otherwise healthy. Participants will be divided into two groups, one receiving ibuprofen and the other dexamethasone as pre-medication 15 minutes before root canal treatment. The treatment involves local anesthesia, rubber dam isolation, working length determination, and instrumentation of the root canals using the ProTaper Next system with sodium hypochlorite irrigation. Calcium hydroxide will be used as an intra-canal medicament before temporary sealing. After instrumentation, patients will be recalled after one week for final obturation and restoration. During the study, patients will mark their pain intensity on a visual analogue scale at 24, 48, and 72 hours after the first visit. Severe pain will be managed with prescribed analgesics. Researchers will monitor the effect of pre-medication on post-endodontic pain at these time points. Patients must attend recall visits and provide written consent. The total study duration includes initial treatment and a one-week follow-up for final restoration.

CONDITIONS

Brief Title

Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain

Who Can Participate

Age: 18Years - 50Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Permanent teeth with acutely inflamed pulp without swelling or draining sinus.
Patients of either gender aged between 18-50 years old.
Systemically healthy patients.
Patients who agree to attend recall appointments and provide written consent.

You will not qualify if you...

Patients on preoperative analgesics and antibiotics.
Teeth with calcified canals and previously treated teeth.
Pregnant and lactating mothers.
Patients who are immunocompromised, anxious, or mentally handicapped.
Patients allergic to any of the test medications.

Research Team

Quratulain Abbasi, BDS

Maha Ali Mirza, BDS

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