Actively Recruiting
The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction
Led by Virtua Health, Inc. · Updated on 2026-05-12
20
Participants Needed
2
Research Sites
161 weeks
Total Duration
On this page
Sponsors
V
Virtua Health, Inc.
Lead Sponsor
P
Pacira Pharmaceuticals, Inc
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the research is to investigate the effect of preoperative Cryoneurolysis of the knee on postoperative pain management in patients undergoing autograft anterior cruciate ligament (ACL) reconstruction (a surgical procedure that makes a new ACL using the patient's own tendon). Cryoneurolysis is an approved process of applying extreme cold temperatures to targeted nerves in order to decrease or eliminate pain. . If you take part in the research, you will be randomly assigned (assigned by chance, like a flip of a coin) to Group A (standard care) or Group B (standard care plus Cryoneurolysis). Participants in both groups will undergo standard ACL reconstruction and receive standard preoperative and postoperative pain management. Participants in Group B only will also receive a standard treatment of Cryoneurolysis to their surgical knee within 7-10 days before their scheduled surgery. Participants in both groups (A \& B) will be asked to bring their remaining postoperative pain medication to their postoperative follow-up appointments for review by study personnel. Participants will also be asked to complete a survey about their knee activity, function and symptoms at these appointments. Your time in the study will last until the completion of the 12-week postoperative follow-up appointment.
CONDITIONS
Official Title
The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 14 and over
- Patients who are patients within the PI's practice
- Patients who can speak and read English
- Patients undergoing autograft ACL reconstruction
- Patients who are opioid nafve
You will not qualify if you...
- Under the age of 14
- Non-English speaking/reading patients
- Patients with Reynauds' syndrome
- Patients with skin disorders or hypo-vascularity
- Patients undergoing allograft ACL reconstruction
- Patients who consistently use opioids preoperatively
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Virtua Orthopedics Burlington
Burlington, New Jersey, United States, 08016
Actively Recruiting
2
Virtua Orthopedics Cherry Hill
Cherry Hill, New Jersey, United States, 08034
Actively Recruiting
Research Team
S
Sean Mc Millan, DO
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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