Actively Recruiting
The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
Led by National Taiwan University Hospital · Updated on 2025-11-19
1344
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).
CONDITIONS
Official Title
The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Out-of-hospital cardiac arrest occurring in the study regions
- Treated by paramedics authorized and capable of administering prehospital medication
You will not qualify if you...
- Cardiac arrest caused by trauma
- Clear signs of death such as decapitation, rigor mortis, livor mortis, or decomposition
- Do Not Resuscitate (DNR) orders or family requests to stop resuscitation
- Known or suspected pregnancy
- No vascular access established before hospital arrival
- Return of spontaneous circulation before medication administration
- No patient contact due to canceled ambulance call or transportation before paramedic arrival
- Received epinephrine before arrival of trial-trained paramedics
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan, 100
Actively Recruiting
Research Team
W
WEN CHU CHIANG, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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