Actively Recruiting
Effect of Premedication With Pronase on Mucosal Cleanliness During EGD
Led by Changhai Hospital · Updated on 2025-02-25
3000
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
Sponsors
C
Changhai Hospital
Lead Sponsor
F
Fujian Provincial Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Gastric cancer and esophageal cancer are common malignant tumors that threaten people's life and health. Esophagogastroduodenoscopy (EGD) is an important tool for screening upper gastrointestinal tumors, especially early tumors, and an effective method for detecting other upper gastrointestinal lesions, including ulcers and polyps. However, during EGD examination, mucus and foam can reduce the cleanliness of the mucosa and limit the operator's visual field, resulting in missed lesions and misdiagnosis. Previous studies have shown that preoperative medication with pronase and dimeticone is correlated with the improvement of upper gastrointestinal mucosal cleanliness. However, the number of samples in such studies is limited, and the artificial judgment is not objective enough to evaluate the cleanliness of upper digestive tract mucosa. And, whether a postural exercise is necessary for premedication with pronase or dimeticone remains unclear. Our team design this experiment to examine the efficacy of using premedication of dimeticone/pronase with a postural exercise on visualization of the mucosa before painless EGD. The investigators aim to provide new evidence to optimize the use of premedication with EGD.
CONDITIONS
Official Title
Effect of Premedication With Pronase on Mucosal Cleanliness During EGD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 218 years and 270 years
- Voluntarily participate in the trial and sign the informed consent
You will not qualify if you...
- Active gastrointestinal bleeding
- Esophageal stricture, complete pyloric obstruction, or gastroparesis from any cause
- Diagnosed malignant tumors of the upper digestive tract
- History of upper gastrointestinal surgery
- Severe heart, liver, or kidney disease or judged unsuitable for painless gastroscopy by a doctor
- Serious mental illness
- Pregnancy or breastfeeding
- Allergy to pronase or dimeticone
- Current participation in other clinical trials or in drug washout/follow-up periods
- Considered unsuitable for this study by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Changhai hosipital
Shanghai, China
Actively Recruiting
Research Team
L
Luowei Wang, MD
CONTACT
L
Lei Xin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
OTHER
Number of Arms
4
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