Actively Recruiting
Effect of Preoperative Silodosin on Feasibility of Ureteral Access Sheath Insertion
Led by Al-Azhar University · Updated on 2023-08-08
2000
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
Sponsors
A
Al-Azhar University
Lead Sponsor
B
Benha University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The ureteral access sheath (UAS) is an ancillary device widely used by urologists to facilitate fast, repeatable, and safe access to ureters and collecting systems; improve visibility; reduce the risk of infection by reducing intrarenal pressure; and protect ureters and scopes when extracting multiple stones during surgery. Insertion of ureteric access sheath may be difficult due to tight ureter, so sometimes preoperative stenting might be needed. Silodosin is an α1A adrenoceptor with high affinity and selectivity for the ureteric muscle, which may reduce ureteral spasm. Oral a1-blockers can reduce intraureteral pressure, and may reduce maximal ureteral access sheath insertion force.¹ Preoperative silodosin protects against significant ureteral injury related to UAS insertion during fURS and decreases postoperative pain level. Silodosin premedication might be an effective and safe technique to replace prestenting.²
CONDITIONS
Official Title
Effect of Preoperative Silodosin on Feasibility of Ureteral Access Sheath Insertion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with renal stones scheduled for flexible ureteroscopy with planned use of ureteral access sheath
You will not qualify if you...
- Patients younger than 18 years old
AI-Screening
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Trial Site Locations
Total: 1 location
1
Urology department - AlAzhar university
Cairo, Egypt
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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