Actively Recruiting
Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
Led by Scarborough General Hospital · Updated on 2026-04-27
3253
Participants Needed
6
Research Sites
79 weeks
Total Duration
On this page
Sponsors
S
Scarborough General Hospital
Lead Sponsor
S
Scarborough Health Network
Collaborating Sponsor
AI-Summary
What this Trial Is About
In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain targets. However, the best targets are unknown. The goal of this clinical trial is to study protocols for magnesium supplementation in people with critical illness, comparing a protocol with higher target level to a protocol with a lower target level. The main question this study aims to answer is whether magnesium supplementation protocols targeting a higher or lower level lead to better 30-day survival and less atrial fibrillation. Participants will not have to do any specific tasks, undergo any additional tests, or complete any surveys.
CONDITIONS
Official Title
Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 16 years or older
- Admission orders written to a medical-surgical intensive care unit at a participating site
- Magnesium replacement protocol ordered
You will not qualify if you...
- Prior enrollment in or withdrawal from MAGNOLIA trial
- Sustained ventricular tachycardia
- Pre-eclampsia
- Myasthenia gravis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Lakeridge Health Ajax-Pickering
Ajax, Ontario, Canada, L1S 2J4
Actively Recruiting
2
Lakeridge Health Bowmanville
Bowmanville, Ontario, Canada, L1C 2N3
Actively Recruiting
3
Lakeridge Health Oshawa
Oshawa, Ontario, Canada, L1G 8A2
Actively Recruiting
4
Scarborough Centenary Hospital
Toronto, Ontario, Canada, M1E 4B9
Actively Recruiting
5
Scarborough General Hospital
Toronto, Ontario, Canada, M1P2V5
Actively Recruiting
6
Scarborough Birchmount Hospital
Toronto, Ontario, Canada, M1W 3W3
Actively Recruiting
Research Team
J
Joshua Craig
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here