Actively Recruiting
Effect of PRP Injection on Voice Recovery After Benign Vocal Fold Surgery
Led by Beni-Suef University · Updated on 2026-05-14
64
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections can improve voice outcomes after microlaryngosurgery in patients with benign vocal fold lesions. The main questions it aims to answer are: Does postoperative PRP injection improve vocal quality compared to conventional surgery alone? Does PRP injection reduce vocal fatigue and improve patients' voice-related quality of life? Researchers will compare 32 patients receiving PRP injections after surgical removal of lesions (intraoperative injection) to 32 patients undergoing conventional surgery without PRP to see if PRP enhances recovery and voice function. Participants will: Undergo microlaryngosurgery to remove benign vocal fold lesions. Receive either a PRP injection to the operated vocal fold or standard postoperative care. Complete voice assessments before surgery and at 1 and 3 months after surgery, including: Auditory perceptual evaluation (GRBAS scale) Videostroboscopy Acoustic and aerodynamic voice analysis Vocal Fatigue Index (VFI) All participants will provide written consent and undergo standard preoperative assessments including medical history, ENT examination, laboratory tests, ECG, and anesthesia evaluation.
CONDITIONS
Official Title
Effect of PRP Injection on Voice Recovery After Benign Vocal Fold Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 50 years
- Diagnosis of a benign vocal fold lesion, including vocal fold polyps, cysts, or nodules
- Failure to respond to conservative management such as voice rest or voice therapy
You will not qualify if you...
- Age younger than 18 years or older than 50 years
- Medically unfit for surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Beni Suef Univesity hospital
Banī Suwayf, Egypt, Egypt, 3220001
Actively Recruiting
Research Team
S
Shaimaa Bakia, Lecturer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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