Actively Recruiting
The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-01-15
80
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation. The main question it aims to answer is: • Is catheter ablation energy (pulse field ablation) revealing a better preservation of the atrial function architecture than with conventional catheter ablation technologies ? Participants will performed 2 IRMs with injection and completed Quality of Life Questionnaires. They participate in the study for 4 months. Researchers will compare 2 arms: * Pulse-Field Ablation * Cryoablation
CONDITIONS
Official Title
The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient age 18 years or older
- Established diagnosis of paroxysmal atrial fibrillation with I/IIa/IIb indication for catheter ablation (ESC 2020 guidelines)
- Episode of atrial fibrillation documented by ECG within the last 12 months
- Ability to provide written informed consent
- If female of childbearing potential, negative serum pregnancy test and use of effective contraception
- Affiliation with French social security system or entitlement
You will not qualify if you...
- Non-paroxysmal atrial fibrillation
- Contraindication to oral anticoagulation
- Presence of intracardiac thrombus
- Previous ablation in the left atrium
- Previous heart surgery
- Significant valvular heart disease (moderate or severe mitral, aortic, or tricuspid valve disease)
- Contraindication to MRI or use of DOTAREM194 contrast (including pacemaker, defibrillator, certain prostheses, severe kidney disease, hypersensitivity to gadoteric acid, severe claustrophobia)
- Patient receiving state medical aid (AME)
- Pregnant or breastfeeding female
- Legal protection such as guardianship or deprived of liberty
- Participation in another interventional study or within exclusion period after a previous study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dr Mikael Laredo
Paris, France, France, 75013
Actively Recruiting
Research Team
M
Mikael Laredo, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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