Effects of Moderate Altitude Rehabilitation on Airway Resistance in COPD Patients Using Forced Oscillation Technique

What this Trial Is About

Researchers are studying the effect of rehabilitation at moderate altitude on airway resistance in patients with COPD. They will use the forced oscillation technique FOT to measure airway resistance parameters Rrs, Xrs, and 94Xrs. The study compares these parameters before and after a pulmonary rehabilitation cycle and also examines differences between low and moderate altitudes. Participants will be randomly assigned to one of three groups one receiving sham air ambient air via an oxygen concentrator, another receiving standardized supplemental oxygen therapy SSOT during training, and a third group training at moderate altitude. Oxygen or sham air will be delivered at 5 liters per minute through a nasal cannula using the EverFlo14 oxygen concentrator during endurance training sessions. During the study, participants will undergo pulmonary rehabilitation over a three-week cycle with measurements taken before and after this period. Assessments include changes in respiratory system resistance and reactance, as well as comparisons of these parameters at low and moderate altitudes. Researchers will monitor the participants clinical stability and oxygen saturation, ensuring adherence to study procedures. The total study duration includes baseline assessment, three weeks of rehabilitation, and follow-up measurements.

Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients