Actively Recruiting
Effect of Remimazolam and Propofol on Postoperative Delirium
Led by Inje University · Updated on 2026-03-27
82
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Remimazolam is an ultra-short acting benzodiazepine agonist which is used widely for general anesthesia and sedation. Remimazolam has several advantages. Remimazolam is rapidly metabolized by tissue esterase that it does not accumulate even after infusion for long periods of time. The presence of reversal agents (flumazenil) is also advantageous. Also, hemodynamic stability compared to propofol gives clinicians preference to use for geriatric anesthesia. However, the study on the effect of remimazolam compared to propofol on postoperative delirium have not been carried out. The purpose of the study is to compare the incidence of postoperative delirium and recovery profile in elderly patients undergoing orthopedic surgery using either remimazolam or propofol.
CONDITIONS
Official Title
Effect of Remimazolam and Propofol on Postoperative Delirium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elderly patients undergoing hip or knee arthroplasty under general anesthesia
- Body mass index greater than 30 kg/m2
You will not qualify if you...
- Moderate to severe liver dysfunction
- Moderate to severe renal dysfunction
- Unable to be extubated in the operation room after surgery
- Dependence on benzodiazepines
- Sensitivity to anesthetic drugs used in the study (benzodiazepines, propofol, remifentanil, fentanyl citrate, rocuronium bromide, sugammadex, flumazenil)
- Acute angle glaucoma
- Use of benzodiazepine, antianxiety drugs, antidepressants, or antipsychotic drugs within 24 hours
- Acute psychotic depression
- History of stroke or cerebrovascular disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sanggye Paik hospital
Seoul, South Korea
Actively Recruiting
Research Team
I
In-Jung Jun, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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