Actively Recruiting
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
Led by Zhujiang Hospital · Updated on 2026-04-17
440
Participants Needed
1
Research Sites
300 weeks
Total Duration
On this page
Sponsors
Z
Zhujiang Hospital
Lead Sponsor
I
Integrated traditional Chinese and Western Medicine Hospital of Southern Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this parallel, multicenter, single-blind randomized controlled trial, mechanical ventilated patients will be randomly assigned to two groups. One receives remimazolam to achieve sedation goals, while the other receives Midazolam. The primary outcome is the effect of remimazolam on duration of mechanical ventilated of critical patients compared to midazolam.
CONDITIONS
Official Title
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Critical ill patients mechanically ventilated within 48 hours of ICU admission and expected to stay in ICU over 72 hours
- Age between 18 and 80 years
- Voluntary informed consent
You will not qualify if you...
- Received surgical treatment within the past 24 hours
- Craniocerebral injury, post neurosurgery, non-drug coma, mental illness, or peripheral neuropathy
- Heart rate less than 50 beats per minute or severe atrioventricular block without pacemaker
- Mean arterial pressure below 55 mmHg despite fluids and vasoactive drugs
- Known or suspected allergy to benzodiazepines, propofol, dexmedetomidine, or opioids
- History of alcohol or drug abuse
- End-stage lung diseases such as pulmonary fibrosis or lung damage
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University
Guangzhou, Guangdong, China, 510282
Actively Recruiting
Research Team
J
Jing Cai
CONTACT
Z
Zhanguo Liu, M.D.PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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