Actively Recruiting

Phase Not Applicable
Age: 40Years +
All Genders
NCT06170944

Effect of Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke

Led by General Hospital of Shenyang Military Region · Updated on 2026-04-27

300

Participants Needed

1

Research Sites

182 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to explore the influence of chronic RIC on collateral status evaluated by DSA in ischemic stroke patients with LAA etiology.

CONDITIONS

Official Title

Effect of Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke

Who Can Participate

Age: 40Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age over 40 years old
  • Diagnosed with ischemic stroke, including transient ischemic attack or cerebral infarction, with symptom onset more than 1 month ago
  • Large artery atherosclerosis of anterior circulation with 50% or more stenosis or occlusion
  • ASITN/SIR collateral circulation score between 0 and 3 based on DSA evaluation
  • First stroke or prior stroke with no significant lasting disability (mRS score 2 or less)
  • Not expected to undergo angioplasty within 12 months as judged by doctor or patient decision
  • Able to provide informed consent
Not Eligible

You will not qualify if you...

  • Severe infection or serious diseases affecting liver, kidney, blood, or endocrine systems
  • History of stroke with severe lasting disability (mRS score 3 or more)
  • Arterial stenosis from aortic dissection, moyamoya disease, vasculitic diseases, viral infections affecting blood vessels, neurosyphilis, intracranial infections, radiation-induced vascular lesions, myofiber dysplasia, sickle cell disease, neurofibromas, benign CNS vascular lesions, postpartum vascular disease, or vasospasm/thrombosis
  • Uncontrolled severe hypertension (systolic ≥180 mmHg or diastolic ≥110 mmHg after treatment)
  • Subclavian artery stenosis 50% or more or subclavian steal syndrome
  • Intracranial hemorrhage within 90 days before enrollment
  • Intracranial tumor, arteriovenous malformation, or aneurysm
  • Severe blood or clotting disorders
  • Retinal or visceral hemorrhage within 30 days
  • Expected major surgery within 30 days before or 12 months after enrollment
  • Previous or planned stent implantation or angioplasty on target vessels within 12 months
  • Contraindications to remote ischemic preconditioning such as serious upper limb injury or vascular problems
  • Damage or lesions in cerebral veins
  • Pregnant or breastfeeding women
  • Participation in other clinical trials within 3 months
  • Life expectancy less than 1 year
  • Other conditions deemed unsuitable by researcher

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

General Hospital of Northern Theater Command

Shenyang, China, 110840

Actively Recruiting

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Research Team

Z

Ziai Zhao

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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