Actively Recruiting
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
Led by Wageningen University · Updated on 2025-07-14
42
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years). The main questions to answer are: * Does whole-body NMES followed by protein intake improve muscle protein synthesis rates during 3 days of bed rest? * Does repeated NMES sessions offer protective effects on muscle mass and function during extended periods of inactivity? Researchers will compare sham electrical electrostimulation, electrical stimulation and electrical stimulation + protein groups to see if whole-body electrostimulation combined with protein intake offers the greatest improvement in muscle protein metabolism and muscle preservation. Participants will: * Undergo 3 days of bed rest while receiving one of the following interventions: * Sham-NMES followed by standard nutrition (CON) * Whole-body NMES followed by standard nutrition(NMES) * Whole-body NMES followed by a bolus of 20g protein (NMES+PRO) * Receive heavy water (D2O) to assess body water turnover. * Undergo leg extension exercises to assess muscle function. * Have quadriceps muscle thickness measured via ultrasound. * Provide saliva samples for analysis. * Have calf circumference measured to monitor changes in muscle mass.
CONDITIONS
Official Title
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged from 18 to 35 years
- Body mass index (BMI) between 18.5 and 30 kg/m2
- Recreationally active by doing non-competitive physical exercise at least once a week for at least 30 minutes
You will not qualify if you...
- Employed or doing a thesis or internship at the department of Human and Animal Physiology at Wageningen University
- Smoking
- Diabetes (Type 1, Type 2, or genetic form)
- Diagnosed cardiovascular disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of prescribed or over-the-counter drugs (except contraceptives)
- Known allergy to lidocaine
- Prone to keloid scar formation
- Conditions affecting mobility and muscle metabolism in lower limbs (e.g., arthritis, neurological disorders, paralysis)
- Regular use of dietary protein or amino acid supplements more than 3 times per week
- Currently engaged in structured progressive resistance training more than 3 times per week
- Personal or family history of thrombosis, epilepsy, seizures, or schizophrenia
- Previous motor, muscle, or lipid metabolism disorders
- Any back, leg, knee, neck, shoulder, or posture-related complaints
- Stomach or gut ulcers or strong history of indigestion
- Contraindications for DXA scans
- Lactose intolerance
- Severe kidney problems
- Pregnant or breastfeeding
- Unable to give consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Wageningen University
Wageningen, Gelderland, Netherlands, 6708WD
Actively Recruiting
Research Team
M
Marlou Dirks, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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