Studying High-Frequency Repetitive Transcranial Magnetic Stimulation to Improve Thinking Skills in Adults with Alcohol Use Disorder Who Have Stopped Drinking

What this Trial Is About

Researchers are investigating the effects of high-frequency repetitive transcranial magnetic stimulation rTMS on improving executive functions in adults with Alcohol Use Disorder AUD who are currently abstinent. AUD can cause lasting changes in brain function and behavior, including difficulties with cognitive flexibility, which may contribute to relapse. This study aims to assess both short- and long-term clinical and cognitive outcomes, as well as brain changes, in this population. Participants will receive daily rTMS treatment targeted to the left dorsolateral prefrontal cortex lDLPFC at 10 Hz frequency, with two sessions per day over 20 business days for four weeks. The location of stimulation is personalized using an algorithm based on brain connectivity. There is also a comparison group receiving sham stimulation with the coil placed on the vertex, following the same schedule and intensity. During the study, participants will undergo cognitive testing and brain imaging at baseline, after the 4-week treatment, and at 6-month follow-up to measure changes in executive functions and brain connectivity. Clinical outcomes, including alcohol craving and symptoms of anxiety and depression, will be monitored throughout. The study lasts about six months from baseline to final follow-up, with safety and treatment adherence carefully observed.

Effect of Repetitive TMS on Executive Function in Alcohol Use Disorder