Actively Recruiting
The Effect of Rifabutin in Mycobacterium Abscessus With Inducible Clarithromycin Resistance
Led by National Taiwan University Hospital · Updated on 2026-04-07
60
Participants Needed
1
Research Sites
24 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Mycobacterium abscessus, one of the most common species of nontuberculous mycobacterium (NTM), poses a significant clinical challenge due to its natural resistance to antibiotics and high treatment failure rates, particularly in lung diseases. Among its subspecies, M. abscessus subspecies abscessus is especially prone to developing inducible resistance to Clarithromycin. This resistance mechanism is primarily due to the activation of the erm(41) gene,which inhibits Clarithromycin from effectively binding to the bacterial ribosome, diminishing its bactericidal efficacy. Rifabutin, an antibiotic widely used in treating tuberculosis and certain NTM infections, has been shown to inhibit the activation of the erm(41) gene by suppressing the whiB7 protein in M. abscessus, suggesting potential efficacy against inducible resistance. However,current evidence primarily stems from in vitro susceptibility studies and case reports, with a notable lack of systematic clinical trials.
CONDITIONS
Official Title
The Effect of Rifabutin in Mycobacterium Abscessus With Inducible Clarithromycin Resistance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 218 years or older
- Diagnosis of pulmonary disease caused by Mycobacterium abscessus confirmed by clinical evaluation and laboratory results
- Antimicrobial susceptibility testing indicating inducible resistance to clarithromycin
- Clinically stable and suitable for antibiotic treatment
- Radiographic evidence of active pulmonary infection
- Willing and able to provide informed consent
You will not qualify if you...
- Known hypersensitivity to rifabutin or intolerance to other study medications
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital Yunlin Branch
Douliu, Yunlin County, Taiwan, 640
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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