Actively Recruiting
Effect of RNS in Treatment-refractory Tourette's Syndrome
Led by Xuanwu Hospital, Beijing · Updated on 2025-01-21
10
Participants Needed
1
Research Sites
255 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant Tourette's Syndrome (TR-TS).
CONDITIONS
Official Title
Effect of RNS in Treatment-refractory Tourette's Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 and 65 years
- Able to provide written informed consent
- Diagnosed with Tourette's syndrome according to DSM-IV-TR criteria and confirmed by a standardized interview
- Yale Global Tic Severity Scale (YGTSS) score of at least 35 for at least 12 months before surgery, with a total motor tic score of 15 or higher
- Have failed conventional medical treatment with adequate doses of three medication classes for at least three months
- Not suitable for behavioral intervention or have had unsuccessful behavioral interventions
- Stable comorbid conditions without suicidal thoughts for at least six months
You will not qualify if you...
- Presence of psychotic disorders
- History of treatments including electroconvulsive therapy, transcranial stimulation, deep brain stimulation, or similar neuromodulation therapies
- Suicide risk indicated by a score of 3 or higher on suicide-related items of HAMD-17
- Difficulty communicating effectively with investigators
- History of traumatic brain injury
- Presence of intracranial or cardiovascular stents
- Substance abuse within the past six months
- Unstable neurological or coagulation disorders
- Women who are pregnant, breastfeeding, or of childbearing potential refusing reliable contraception during the study
- Participation in other clinical studies within three months before enrollment
- Any other conditions considered unsuitable by the study team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, China, 100053
Actively Recruiting
Research Team
H
Hongxing Wang, MD & PhD
CONTACT
H
Huang Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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