Seizure treatment with olfactory training: a preliminary trial.
Yasin Yilmaz, Bengi Gul Turk, Merve Hazal Ser...
https://pubmed.ncbi.nlm.nih.gov/36066675Actively Recruiting
Early Phase 1
Age: 18Years +
All Genders
ID07116421
Effect of 2-phenylethanol Odor Exposure on Ictal Apneic Episode Occurrence Rate in Patients With Epilepsy
Led by Vanderbilt University Medical Center · Updated on 2025-08-11
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether exposure to rose scent can reduce the risk of sudden unexpected death in epilepsy (SUDEP) by studying adult patients with epilepsy undergoing inpatient monitoring. The study focuses on understanding how rose scent exposure affects seizure-related breathing difficulties, using electroencephalography (EEG) and respiratory monitoring. This early-phase trial aims to uncover potential new ways to help patients with epilepsy by exploring the link between smell and seizure activity. Participants will first undergo 24 hours of routine EEG monitoring without rose scent exposure while wearing a respiratory belt to measure breathing. Then, for another 24 hours, they will continue EEG and respiratory monitoring while a diffuser releases rose essential oil scent into their hospital room. The rose scent is given as three drops diffused continuously over 24 hours. Mood assessments and a smell identification test are also done during the study period. During the 48-hour study, participants will be monitored closely with EEG and a respiratory belt to record seizure and breathing events. They will complete mood surveys before and after rose scent exposure and take a smell recognition test at the start. The study measures the number of seizure episodes and breathing pauses during both 24-hour periods. Participants are free to engage in normal activities during their hospital stay, with the main requirement being to wear the respiratory belt most of the time.
CONDITIONS
Brief Title
Effect of Rose Odor Exposure on Ictal Apnea
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult epilepsy patients over the age of 18
- Admission to the inpatient epilepsy monitoring unit (EMU) at Vanderbilt University Medical Center (VUMC)
- Undergoing observational EEG monitoring without treatment involving seizure medication changes or other interventions for at least 48 hours
You will not qualify if you...
- Patients under the age of 18
- Patients receiving EEG monitoring without interventions from baseline for less than 48 hours
- Patients who are not receiving EEG monitoring as a part of their inpatient admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Baseline Monitoring
Duration - 24 hours
Participants undergo routine inpatient observational EEG monitoring on room air while wearing a respiratory belt to measure respiratory function.
Continuous monitoring over 24 hours
Rose Scent Exposure Treatment
Duration - 24 hours
Participants continue routine inpatient EEG monitoring while exposed to rose scent via an essential oil diffuser in their room and wearing a respiratory belt for respiratory monitoring.
Continuous monitoring over 24 hours
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
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Research Team
B
Brigitte Jia, BA
W
William P Nobis, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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Teri B O'Neal, Sanjay Shrestha, Harsimar Singh...
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