Studying the Effects and Safety of Taking Ibuprofen with Dextrose Prolotherapy Injections to Treat Knee Osteoarthritis in Adults Aged 45 to 75

What this Trial Is About

Researchers are evaluating the effect and safety of using non-steroidal anti-inflammatory drugs NSAIDs alongside dextrose prolotherapy DPT injections in adults with knee osteoarthritis OA. This randomized, double-blinded, controlled trial involves men and women aged 45 to 75 with chronic knee OA, aiming to expand on earlier pilot study findings that suggested combining NSAIDs with DPT does not reduce treatment effectiveness and is safe. Participants will be randomly assigned to receive either ibuprofen or a placebo while undergoing three ultrasound-guided knee injections of 4 mL of 25% dextrose mixed with 1% lidocaine. These injections occur at baseline, week 4, and week 8, each accompanied by a 7-day supply of the assigned study drug. Participants are advised to avoid other pain medications and treatments during the study. During the 12-week study, participants will complete pain and function assessments using the Numeric Pain Rating Scale NPRS and Knee Injury and Osteoarthritis Outcome Score KOOS at weeks 0, 4, 8, and 12. Researchers will monitor changes in these scores to determine the impact of ibuprofen versus placebo combined with DPT. Safety and treatment adherence will be closely followed throughout the trial period.

The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis