Actively Recruiting
Effect and Safety of Benzathine Penicillin Combined With Etanercept on Spondyloarthritis
Led by Nanfang Hospital, Southern Medical University · Updated on 2025-06-26
340
Participants Needed
6
Research Sites
111 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to verify the clinical feasibility of Benzathine penicillin (BPG) /Etanercept (ETN) combination regimen in patients with spondyloarthritis (SpA) and at the same time compare Benzathine penicillin /Etanercept combination regimen and Etanercept maintenance therapy in reducing disease activity, improving patients' clinical symptoms and body function scores, enhancing quality of life, improving imaging performance and safety.
CONDITIONS
Official Title
Effect and Safety of Benzathine Penicillin Combined With Etanercept on Spondyloarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily participate and sign informed consent
- Aged 18 to 59 years
- Diagnosed with spinal arthritis meeting 2009 ASAS axial spondyloarthritis or 2011 ASAS peripheral spondyloarthritis criteria
- Currently in a relatively active disease period (ASDAS-CRP > 1.2)
You will not qualify if you...
- Have nasopharyngitis, active tuberculosis, inflammatory bowel disease, other infections, rheumatic or immune diseases, malignant tumors, or other bone and joint diseases
- Allergic to components of the experimental drug
- Severe liver or kidney function abnormalities (liver enzymes ≥ 2 times normal; creatinine ≥ 2 times normal)
- Pregnant, preparing for pregnancy, or breastfeeding
- Moderate to severe heart failure (NYHA grades 3-4)
- Other conditions unsuitable for etanercept or study drugs as judged by researchers
- Active gastrointestinal ulcer or bleeding
- Acute streptococcal infection symptoms or abnormal ASO, ADNS, or CRP levels
- Judged unsuitable for participation by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Anhui Provincial Hospital
Hefei, Anhui, China, 230001
Not Yet Recruiting
2
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400010
Not Yet Recruiting
3
Nan Fang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510080
Actively Recruiting
4
Nan Fang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
5
Inner Mongolia People's Hospital
Hohhot, Inner Mongolia, China, 010010
Not Yet Recruiting
6
Ganzhou People's Hospital
Ganzhou, Jiangxi, China, 341000
Not Yet Recruiting
Research Team
J
Jun Xiao
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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