Actively Recruiting
Effect of a SI-MMC on the IVR Rate After Ureteroscopy for UTUC
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2024-01-31
100
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to evaluate the intravesical recurrence (IVR) rate after ureteroscopy (diagnostic or treatment) for upper tract urothelial carcinoma (UTUC) followed by an adjuvant single instillation of Mitomycin C (SI-MMC). The main question it aims to answer are: * What is the total and time to IVR after 2 years after ureteroscopy (diagnostic or treatment) for UTUC * How is the IVR compared with a historical cohort (no SI-MMC) * What is the time to IVR after 2 years in patients who subsequently received treatment by endoscopy vs. radical nephroureterectomy (RNU) * What is the additional value of a SI-MMC on time to IVR after RNU + adjuvant MMC in patients who were evaluated by ureteroscopy prior to RNU
CONDITIONS
Official Title
Effect of a SI-MMC on the IVR Rate After Ureteroscopy for UTUC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients suspect for having non-metastatic disease and planned for ureteroscopy (diagnostic or treatment) and adjuvant single instillation of Mitomycin C
- Age ≥18 years
- Written informed consent
You will not qualify if you...
- History of histological proven urothelial carcinoma of the bladder, including carcinoma in situ
- History of histological proven UTUC in the contralateral kidney
- Concurrent bladder tumour found pre-operatively or per-operatively
- Patients where it is not feasible to obtain histology by biopsies intra-operatively
- Known Mitomycin C
- Renal transplantation
AI-Screening
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Trial Site Locations
Total: 1 location
1
AmsterdamUMC
Amsterdam, Netherlands
Actively Recruiting
Research Team
J
Joyce Baard, MD, MSc
CONTACT
O
Orlane Figaroa, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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