Actively Recruiting

Phase 4
Age: 4Years - 12Years
All Genders
NCT06699199

Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient

Led by King Abdulaziz University · Updated on 2025-03-06

50

Participants Needed

1

Research Sites

86 weeks

Total Duration

On this page

Sponsors

K

King Abdulaziz University

Lead Sponsor

K

King Fahd Medical Research Centre

Collaborating Sponsor

AI-Summary

What this Trial Is About

This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children. It will also provide a deeper insight into different products of the same agent and its effectiveness in Arresting dental caries. The main questions it aims to answer are: What is the clinical impact of silver diamine fluoride application in caries-active children? What is the antimicrobial effect of silver diamine fluoride in oral microbial inhabitants? Researchers will compare silver diamine fluoride (SDF)only and silver diamine fluoride+ potassium iodide(SDF+KI) to see which materials substantially affect on dental caries and oral microbial inhabitants Participants/Parent will: The parent will fill out a comprehensive data sheet for the child (childhood and current dental and medical history) Visit the dental clinic to Receive one of 2 (SDF or SDF+KI) treatment applications once Visit the clinic a 2nd time for a 2-4 week Treatment Follow-up Go through the sample collection process twice( pre- and 2-4 weeks post- Treatment) Sample collection including (Saliva- Biofilm and caries tissue sample)

CONDITIONS

Official Title

Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient

Who Can Participate

Age: 4Years - 12Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Healthy patients
  • Patients within 4-10 years of age
  • Presence of at least one deciduous tooth with a cavitated caries lesion directly accessible
Not Eligible

You will not qualify if you...

  • Presence of irreversible pulpititis or necrosis
  • Extensive lesion that has already been restored
  • Lesion surface is hard and smooth
  • Children with inherited or systemic medical conditions
  • Children with significant medication history or who have taken antibiotics within the last 3 months
  • Children who had topical fluoride treatment within the previous 2 weeks

AI-Screening

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Trial Site Locations

Total: 1 location

1

University Dental hospital of King Abdulaziz University

Jeddah, Mecca Region, Saudi Arabia, 80209

Actively Recruiting

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Research Team

D

Dr.Doaa Y Jamal, BDS, MSc, SBPD

CONTACT

P

Prof. (Dr.) Abdullah S AlMushayt, BDS, MSc, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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