Actively Recruiting
Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient
Led by King Abdulaziz University · Updated on 2025-03-06
50
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
Sponsors
K
King Abdulaziz University
Lead Sponsor
K
King Fahd Medical Research Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children. It will also provide a deeper insight into different products of the same agent and its effectiveness in Arresting dental caries. The main questions it aims to answer are: What is the clinical impact of silver diamine fluoride application in caries-active children? What is the antimicrobial effect of silver diamine fluoride in oral microbial inhabitants? Researchers will compare silver diamine fluoride (SDF)only and silver diamine fluoride+ potassium iodide(SDF+KI) to see which materials substantially affect on dental caries and oral microbial inhabitants Participants/Parent will: The parent will fill out a comprehensive data sheet for the child (childhood and current dental and medical history) Visit the dental clinic to Receive one of 2 (SDF or SDF+KI) treatment applications once Visit the clinic a 2nd time for a 2-4 week Treatment Follow-up Go through the sample collection process twice( pre- and 2-4 weeks post- Treatment) Sample collection including (Saliva- Biofilm and caries tissue sample)
CONDITIONS
Official Title
Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy patients
- Patients within 4-10 years of age
- Presence of at least one deciduous tooth with a cavitated caries lesion directly accessible
You will not qualify if you...
- Presence of irreversible pulpititis or necrosis
- Extensive lesion that has already been restored
- Lesion surface is hard and smooth
- Children with inherited or systemic medical conditions
- Children with significant medication history or who have taken antibiotics within the last 3 months
- Children who had topical fluoride treatment within the previous 2 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Dental hospital of King Abdulaziz University
Jeddah, Mecca Region, Saudi Arabia, 80209
Actively Recruiting
Research Team
D
Dr.Doaa Y Jamal, BDS, MSc, SBPD
CONTACT
P
Prof. (Dr.) Abdullah S AlMushayt, BDS, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here