Actively Recruiting
The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments
Led by University of Texas Southwestern Medical Center · Updated on 2026-01-26
28
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.
CONDITIONS
Official Title
The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 65 years old
- No significant underlying medical problems based on medical history and physical exam
- Normal resting electrocardiogram
You will not qualify if you...
- Known heart disease
- Chronic medical conditions requiring regular treatment, including cancer, diabetes, neurological diseases, or uncontrolled hypertension
- Pregnant, planning pregnancy, or breastfeeding (confirmed by urine pregnancy test)
- Taking medications that affect thermoregulation, such as beta blockers or certain calcium channel blockers
- Current smokers or regular smokers within the past 3 years
- Body mass index of 31 kg/m2 or higher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
E
Erin M Harper, B.S.
CONTACT
E
Elizabeth A Gideon, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here