Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
Healthy Volunteers
NCT07050264

The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

Led by University of Texas Southwestern Medical Center · Updated on 2026-01-26

28

Participants Needed

1

Research Sites

126 weeks

Total Duration

On this page

Sponsors

U

University of Texas Southwestern Medical Center

Lead Sponsor

N

National Institute of General Medical Sciences (NIGMS)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

CONDITIONS

Official Title

The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

Who Can Participate

Age: 18Years - 65Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Between 18 and 65 years old
  • No significant underlying medical problems based on medical history and physical exam
  • Normal resting electrocardiogram
Not Eligible

You will not qualify if you...

  • Known heart disease
  • Chronic medical conditions requiring regular treatment, including cancer, diabetes, neurological diseases, or uncontrolled hypertension
  • Pregnant, planning pregnancy, or breastfeeding (confirmed by urine pregnancy test)
  • Taking medications that affect thermoregulation, such as beta blockers or certain calcium channel blockers
  • Current smokers or regular smokers within the past 3 years
  • Body mass index of 31 kg/m2 or higher

AI-Screening

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Trial Site Locations

Total: 1 location

1

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas

Dallas, Texas, United States, 75231

Actively Recruiting

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Research Team

E

Erin M Harper, B.S.

CONTACT

E

Elizabeth A Gideon, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

4

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The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments | DecenTrialz