Actively Recruiting
The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments
Led by University of Texas Southwestern Medical Center · Updated on 2026-05-26
28
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how burn survivors regulate their body temperature after exercise in hot environments, focusing on whether their recovery is slower compared to non-burned individuals. The study evaluates the effects of impaired heat dissipation due to reduced skin blood flow and sweating at grafted sites and uses simulated burn injury to replicate burn conditions. The goal is to understand the rate at which core body temperature and thermoregulation markers return to normal after exercise with and without simulated burns. Participants will be randomly assigned to one of four groups: exposure to hot and humid conditions with or without simulated burn injury, and exposure to hot and dry conditions with or without simulated burn injury. The simulated burn injury involves applying an absorbent and impermeable material over 60% of the participant's body to mimic the effects of a burn. The study does not include any masking or blinding. During the study, core body temperature and heart rate will be measured from baseline through 60 minutes of recovery after exercise. Participants will undergo assessments during exposure to the different conditions to track thermoregulation and cardiovascular responses. The total participation time includes exercise followed by a one-hour recovery period, with safety and health status monitored throughout the trial.
CONDITIONS
Brief Title
The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 65 years of age
- Free of significant underlying medical problems based on medical history, physical exam, and normal resting electrocardiogram
You will not qualify if you...
- Known heart disease
- Chronic medical conditions requiring regular therapy such as cancer, diabetes, neurological diseases, or uncontrolled hypertension
- Pregnant, planning to become pregnant, or breastfeeding (confirmed by urine pregnancy test in females)
- Taking medications that affect thermoregulatory response, including beta blockers and certain calcium channel blockers
- Current smokers or those who have regularly smoked within the past 3 years
- Body mass index of 31 kg/m2 or higher
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Each exposure includes 60 minutes of recovery after exercise
Participants undergo simulated burn injury or no injury exposure under hot and humid or hot and dry conditions to study post-exercise recovery.
Multiple visits for each exposure condition in a crossover design
Trial Site Locations
Total: 1 location
1
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
E
Erin M Harper, B.S.
E
Elizabeth A Gideon, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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