Actively Recruiting
Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
Led by Tata Main Hospital · Updated on 2026-01-09
106
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study describes a randomized controlled trial designed to evaluate the impact of a single intravenous dose of magnesium sulfate on postoperative analgesic consumption in patients undergoing laparoscopic cholecystectomy. The primary aim is to determine if magnesium sulfate can reduce postoperative morphine usage and its associated side effects. The study will involve 106 patients (53 per arm), aged 18-65, classified as ASA physical status I or II, who are scheduled for elective laparoscopic cholecystectomy. Participants will be randomly assigned to receive either 30 mg/kg intravenous magnesium sulfate or a placebo (normal saline), alongside standard anesthetic care. Secondary outcomes include pain scores, the time until rescue analgesia is needed, and the monitoring of hemodynamic responses and potential adverse events. Statistical analysis will utilize descriptive statistics, chi-square tests, and t-tests or Mann-Whitney U-tests to compare the two groups.
CONDITIONS
Official Title
Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years
- Male or female
- ASA Physical Status I or II
- Scheduled for elective laparoscopic cholecystectomy
You will not qualify if you...
- Patient refusal to participate
- Body mass index (BMI) greater than 30 kg/m²
- Obstructive sleep apnea (OSA)
- Renal, hepatic, or cardiovascular dysfunction including cardiac conduction disorders
- Use of long-term calcium channel blockers or magnesium supplements
- History of opioid or analgesic abuse
- Psychiatric illness
- Surgical duration less than 1 hour or more than 3 hours
- Conversion from laparoscopic to open surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Tata Main Hospital
Jamshedpur, Jharkhand, India, 831001
Actively Recruiting
2
Dr.Deb Sanjay Nag
Jamshedpur, Jharkhand, India, 831011
Actively Recruiting
Research Team
D
Dr Deb Sanjay Nag, MD
CONTACT
H
Himanshu Kumar, DNB
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here