Study of Single Intravenous Dose of Magnesium Sulfate to Reduce Pain Medication After Laparoscopic Gallbladder Surgery in Adults Aged 18 to 65

What this Trial Is About

Researchers are evaluating the effect of a single intravenous dose of magnesium sulfate on postoperative pain control in patients undergoing laparoscopic cholecystectomy. This randomized controlled trial aims to see if magnesium sulfate can reduce morphine use and its side effects after surgery. The study involves adults aged 18 to 65, classified as ASA physical status I or II, scheduled for elective laparoscopic gallbladder removal. Participants will be randomly assigned to receive either 30 mgkg of intravenous magnesium sulfate diluted in 100 ml of normal saline or an equivalent volume of normal saline as a placebo at the start of anesthesia. Both groups will also receive standard multimodal pain relief with intravenous diclofenac and paracetamol at the time the surgical ports are closed. Rescue morphine will be given if pain reaches a certain level. The study monitors pain levels, timing of analgesic use, hemodynamic responses, and any adverse events during and after surgery. During the 24 hours following surgery, patients will be closely observed for total morphine consumption and pain scores using the Visual Analogue Scale. Researchers will also track the time until rescue pain medication is required and monitor vital signs to assess safety. Data analysis will compare the magnesium and placebo groups to determine any differences in pain control and side effects. The total participation time covers the intraoperative period and 24 hours post-operation.

Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy