Actively Recruiting
The Effect of Sirolimus on Immunizations During the Treatment of Kaposiform Hemangioendothelioma
Led by Children's Hospital of Fudan University · Updated on 2025-06-27
174
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To research and explore the antibody protection and immune memory after vaccination in children with KHE during sirolimus administration. To explore the feasibility (safety and efficacy) of vaccination in a timely manner during the administration of sirolimus in children with KHE. To search for back-up plans for vaccination regimens for KHE patients taking sirolimus in children who do not respond to primary vaccination.
CONDITIONS
Official Title
The Effect of Sirolimus on Immunizations During the Treatment of Kaposiform Hemangioendothelioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- KHE patients treated with sirolimus
- Participants vaccinated with live attenuated or inactivated vaccines in a timely manner after immunological evaluation
- Healthy children with no immune deficiencies
- Control participants vaccinated according to the National Immunization Program
- Participants matched by age to the case group
You will not qualify if you...
- Positive for HBsAg, HBeAg, or having other active infectious diseases
- History of immunodeficiency or low immunoglobulin levels
- Autoimmune disease or fever at the time of blood collection
- Use of other medications or surgery
- Having other bleeding disorders
- Having other solid tumors or blood-related cancers
- Withdrawal of informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 201102
Actively Recruiting
Research Team
K
Kai Li, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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