Actively Recruiting
Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
Led by University of Miami · Updated on 2026-03-23
80
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
Sponsors
U
University of Miami
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
CONDITIONS
Official Title
Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled for microsurgical clipping of an unruptured cerebral artery aneurysm or endovascular treatment of unruptured cerebral aneurysms
- At least 18 years old
- Able and willing to give informed consent
You will not qualify if you...
- Having dissecting, traumatic, or mycotic brain aneurysm
- Pregnant or breastfeeding women, or positive pregnancy test
- Any significant psychiatric or psychological disorder preventing study completion
- Known HIV infection or other immunodeficiency
- Renal or liver failure
- Interstitial pneumonitis
- History of lymphoma or skin cancer
- Hypersensitivity to Sirolimus
- Severe or unstable chronic condition affecting safety or efficacy assessment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
Research Team
J
Jayro Toledo, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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