Actively Recruiting
Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients
Led by Kafrelsheikh University · Updated on 2024-09-05
60
Participants Needed
1
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to explore the effect of SGLT2i on the levels of cardiac biomarkers, inflammatory and stress markers in Egyptian heart failure patients to provide a better understanding of mechanism that might assist in tailoring treatment strategies in patients with various forms of HF especially in Egyptian population. Also understand how biomarkers may be employed to predict risk in patients receiving SGLT2i or identification of those who may derive the most benefit from SGLT2i in the means of individualized medicine.
CONDITIONS
Official Title
Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged more than 18 years old
- Heart failure patients with cardiac function classified as NYHA class II-IV
- Patients receiving standard heart failure therapy according to guidelines, including ACE inhibitors, ARBs, ARNI, beta blockers, mineralocorticoid receptor antagonists, and diuretics as needed
- All patients must have signed informed consent
You will not qualify if you...
- Patients with acute cardiovascular illness or severe sepsis that could affect inflammatory markers
- Patients with severe congenital heart disease, myocarditis, or valvular heart disease
- Female patients who are pregnant or breastfeeding
- Patients with malignant tumors, hyperfunctioning thyroid, multiple organ failure, or severely reduced kidney function (eGFR <20 mL/min/1.73 m²)
- Patients with verbal communication disorders or cognitive impairment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kafrelsheikh University Hospital
Kafr ash Shaykh, Egypt, 33516
Actively Recruiting
Research Team
N
Nada Nabil mohammed elsalhey, BSC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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