Actively Recruiting
Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Led by The Third Affiliated hospital of Zhejiang Chinese Medical University · Updated on 2024-12-17
144
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ischemic stroke is a common clinical disease, often accompanied by dysphagia. At present, clinical treatment for patients with dysphagia after ischemic stroke is limited. The emergence of NGF has surprised the field of neurorehabilitation, but the clinical effect is not satisfactory. The main problem is that NGF is a macromolecular material with a molecular weight of 13.4 KD, which is difficult to penetrate the blood brain barrier. A large number of previous studies in our team have found that electroacupuncture with specific stimulation mode can open the blood brain barrier and induce NGF into the brain. Therefore, the purpose of this study is to investigate the effect of specific mode electroacupuncture stimulation combined with NGF treatment on patients with dysphagia after ischemic stroke and to explore the mechanism of this combination therapy to improve brain function, which creates a new method and theoretical basis for nerve rehabilitation of integrated traditional Chinese and Western medicine.
CONDITIONS
Official Title
Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with first-ever ischemic stroke confirmed by CT or MRI
- Stroke onset between 15 and 180 days ago
- Aged between 18 and 80 years, any gender
- Diagnosed with dysphagia confirmed by videofluoroscopic swallowing study (VFSS)
- Able to accept and comply with acupuncture, electroacupuncture, and gluteal intramuscular injections
- Provided signed consent and willing to participate in the trial
You will not qualify if you...
- Dysphagia present before ischemic stroke or caused by other reasons
- Severe cognitive impairment
- Severe heart, liver, or kidney dysfunction, or severe blood clotting problems
- Other abnormal test results making participation unsuitable
- Multiple strokes, brain surgery history, or stroke caused by trauma or tumors
- Severe neurological deficits before stroke, including vision, hearing, speech, or movement problems
- Women who are lactating, pregnant, or planning pregnancy
- History of fainting during needle insertion or skin infections at acupuncture sites
- Presence of a cardiac pacemaker
- Allergy to nerve growth factor (NGF)
- Unable to undergo videofluoroscopic swallowing study (VFSS)
- Use of medications affecting brain activity within past 2 months
- Currently or recently (within 3 months) participating in other clinical trials
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Hangzhou, Zhejiang, China, 310005
Actively Recruiting
Research Team
X
Xianming Lin, PHD
CONTACT
X
Xiaoyang Yu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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