Actively Recruiting
Comparative Evaluation of Hypericum Perforatum (St. John's Wort) on Pain Level in Treating Recurrent Aphthous Stomatitis: A Randomized Clinical Trial
Led by Batman University · Updated on 2025-02-25
75
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of St. John's wort extract on patients with Recurrent Aphthous Stomatitis (RAS), a condition that causes painful mouth ulcers and lacks a definitive treatment. The study aims to compare the healing and pain relief benefits of St. John's wort with two other commonly used treatments: triamcinolone acetonide, a corticosteroid, and hyaluronic acid gel. RAS causes discomfort in oral functions, and this research seeks to find better ways to reduce pain and promote ulcer healing.
CONDITIONS
Brief Title
Effect of St. John's Wort in the Treatment of Recurrent Aphthous Stomatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- History of recurrent aphthous stomatitis for at least 2 years
- Presence of a current ulcer in an easily accessible area of the mouth
- Ulcer onset within the past 48 hours
You will not qualify if you...
- Allergy to any of the substances used in the study treatments
- Pregnancy or breastfeeding
- Use of steroids, vitamins, antibiotics, antihistamines, oral retinoids, or immune system regulating agents for ulcer treatment within the past 3 months
- History of systemic disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 7 days
Participants apply one of the study medications to the ulcer area 4 times a day for 7 days.
Visits on days 0, 3, 5, and 7 to assess pain levels and ulcer size
Trial Site Locations
Total: 1 location
1
Batman University
Batman, Centre/Batman, Turkey (Türkiye), 72100
Actively Recruiting
Research Team
R
Rojdan F GÜNEŞ UYSAL, PhD
G
Giray G TEKİN, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Frequently Asked Questions
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