Actively Recruiting
Effect of Standard Nutrition Therapy on Nutritional Status and Prognosis in Locoregionally Advanced Nasopharyngeal Carcinoma Patients With Malnutrition
Led by Sun Yat-sen University · Updated on 2026-05-11
266
Participants Needed
1
Research Sites
432 weeks
Total Duration
On this page
Sponsors
S
Sun Yat-sen University
Lead Sponsor
Z
Zhongnan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multicenter, randomized controlled, phase III clinical trial. The purpose of this study is to evaluate the efficacy of standard nutrition treatment versus conventional nutrition treatment in local advanced nasopharyngeal carcinoma patients.
CONDITIONS
Official Title
Effect of Standard Nutrition Therapy on Nutritional Status and Prognosis in Locoregionally Advanced Nasopharyngeal Carcinoma Patients With Malnutrition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly histologic diagnosis of nasopharyngeal carcinoma (WHO II/III)
- All genders, aged 18 to 65 years
- Karnofsky performance status (KPS) 60 80
- Clinical stage III to IVa (AJCC/UICC 8th edition)
- No significant digestive, nutritional, metabolic, or endocrine diseases
- No significant cardiac, respiratory, kidney, or liver diseases
- No prior radiotherapy, chemotherapy, or other anti-tumor treatments including immunotherapy
- White blood cell count 60 4�d7109/L, neutrophil granulocyte count 60 1.5�d7109/L, hemoglobin 60 9 g/L, platelet count 60 100�d7109/L
- Total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) less than 2.5 times the upper limit of normal
- Adequate renal function: BUN/CRE 60 1.5 times upper limit of normal or creatinine clearance 60 60 ml/min (Cockcroft-Gault formula)
- No contraindications to chemotherapy or radiotherapy
- Signed informed consent form
You will not qualify if you...
- Contraindications to PEG/PEJ such as coagulopathy, recent anticoagulant or aspirin use, gastric ulcers or bleeding history, portal hypertension with varices, pyloric obstruction after gastrectomy
- Presence of distant metastases
- Other malignant tumors
- Participation in other clinical trials
- Drug or alcohol addiction
- Lack of full legal capacity
- Mental disorders
- Pregnancy or breastfeeding
- Severe complications such as uncontrolled hypertension
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
J
Jingjing Miao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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