Actively Recruiting
Effect of Statins on Crohn's Disease
Led by Stanford University · Updated on 2026-02-27
20
Participants Needed
1
Research Sites
202 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if statins work to prevent strictures in adults with Crohn's disease. The main question it aims to answer is: * Can statins reduce the formation of strictures in participants with stricturing Crohn's disease? Researchers will compare statins to a placebo (a look-a-like substance that contains no drug) to see if statins work to prevent strictures from forming. Participants will: * Take statins or a placebo every day for 6-12 months * Visit the clinic for lab tests twice after starting either statins or placebo * Complete questionnaires about symptoms and medications * Respond to monthly check-ins (via phone call) during participation
CONDITIONS
Official Title
Effect of Statins on Crohn's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Established diagnosis of stricturing Crohn's disease
- Scheduled for surgical resection of terminal ileum strictures at Stanford University or Dr. Phillip Fleshner's colorectal surgery practice in Los Angeles
You will not qualify if you...
- Pregnant, nursing, or planning to become pregnant in the next 6-12 months
- Severe renal dysfunction (stage 5 chronic kidney disease or end-stage renal disease)
- Known allergy or prior serious reaction to statin therapy (e.g., rhabdomyolysis)
- Current use of cyclosporine
- Current use of statin therapy before starting the study
- Active liver disease beyond metabolic dysfunction-associated steatotic liver disease with unexplained persistent liver enzyme elevations
- Current use of antifungals (ketoconazole, itraconazole, voriconazole), fibrate drugs, macrolide antibiotics (erythromycin, clarithromycin), protease inhibitors (ritonavir, lopinavir), calcium channel blockers (verapamil, diltiazem), amiodarone, warfarin, or colchicine without doctor approval
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
T
Touran Fardeen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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