Actively Recruiting
Effect of Stem Cell Infusion Time on aGVHD in Patients With Nonmalignant Hematologic Diseases
Led by Anhui Provincial Hospital · Updated on 2025-06-26
198
Participants Needed
6
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To observe the effect of stem cell infusion on the development of acute graft- versus-host disease (aGVHD) in patients with nonmalignant hematologic diseases after allogeneic peripheral blood hematopoietic stem cell transplantation (allo-PBSCT)
CONDITIONS
Official Title
Effect of Stem Cell Infusion Time on aGVHD in Patients With Nonmalignant Hematologic Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Definite diagnosis of malignant hematologic disease before transplantation
- Age between 12 and 60 years old
- No gender or race restrictions
- Planned first allogeneic peripheral blood hematopoietic stem cell transplantation (allo-PBSCT)
- Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
- No serious organ failure or active infection
- Willingness to participate in an open randomized controlled study on stem cell infusion timing
- Signed informed consent form or legal representative consent if patient unable to sign
You will not qualify if you...
- Severe organ dysfunction or disease affecting heart, liver, kidneys, or pancreas
- Pregnancy
- Refusal to participate in the randomized controlled study on stem cell infusion timing
- Any life-threatening disease or condition that may compromise safety or study results
- Drug dependence, uncontrolled psychiatric disorders, or cognitive dysfunction
- Participation in other clinical studies affecting aGVHD within the past 3 months
- Anticipated inability to adhere to study procedures due to financial or other issues
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Hefei, Anhui, China, 230036
Actively Recruiting
2
Peking University First Hospital
Beijing, Beijing Municipality, China, 100000
Actively Recruiting
3
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450000
Actively Recruiting
4
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430000
Actively Recruiting
5
Rui Jin Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
6
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
X
Xiaoyu Zhu, ph.D
CONTACT
Y
Yue Wu, M.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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