Actively Recruiting
Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies Post UCBT
Led by Anhui Provincial Hospital · Updated on 2025-12-23
134
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To observe the effect of stem cell infusion on the development of acute graft- versus-host disease (aGVHD) in patients with malignant hematologic diseases after single-unit unrelated cord blood transplantation (sUCBT).
CONDITIONS
Official Title
Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies Post UCBT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Definite diagnosis of malignant hematologic disease before transplantation, no limits on age, gender, or race
- Achieved complete remission with negative minimal residual disease prior to transplantation
- Planned to receive single-unit umbilical cord blood transplantation for the first time
- Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
- No serious organ failure or active infection
- Willing to participate in an open randomized controlled study on infusion timing and aGVHD
- Signed informed consent form or legal representative signed if participant unable
You will not qualify if you...
- Severe organ dysfunction or disease affecting heart, liver, kidneys, or pancreas
- Any life-threatening condition or organ dysfunction compromising safety or study results
- Drug dependence, uncontrolled psychiatric disorders, or cognitive dysfunction
- Participation in other clinical studies affecting aGVHD within past 3 months
- Investigator judgment deeming participant unsuitable due to adherence or other issues
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital
Hefei, Anhui, China, 230001
Actively Recruiting
Research Team
X
Xiaoyu Zhu, Ph.D
CONTACT
Y
Yue Wu, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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