Actively Recruiting
Effect of a Sugar Replacement on Blood Glucose Levels in Healthy Adults
Led by University of Aberdeen · Updated on 2025-04-30
50
Participants Needed
1
Research Sites
36 weeks
Total Duration
On this page
Sponsors
U
University of Aberdeen
Lead Sponsor
Y
Yakult Honsha Co., LTD
Collaborating Sponsor
AI-Summary
What this Trial Is About
Diabetes and cardiovascular disease account for millions of deaths per year. One of the risk factors for both conditions is high blood sugar, particularly after eating (postprandial hyperglycaemia). Lowering blood sugar levels after a meal is expected to have a positive effect on preventing metabolic and cardiovascular diseases and improving the metabolic control of those who already suffer from these conditions. The aim of this study is to investigate the effect of Oligomate® (beta-galacto-oligosaccharide) on postprandial glycaemia when used as a partial replacement of glycaemic carbohydrates in a beverage in otherwise healthy volunteers. Volunteers will be given water with either Oligomate® or glucose (control) added. Blood samples will be collected at eight time points (two before drinking the beverage and six after) to measure glucose and insulin levels.
CONDITIONS
Official Title
Effect of a Sugar Replacement on Blood Glucose Levels in Healthy Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy men or women
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m^2
- Aged between 18 and 65 years
- Willing and able to follow study procedures and safety guidelines
- Able to give informed consent
- Premenopausal women must have a regular menstrual cycle or be using hormonal contraception
You will not qualify if you...
- Diagnosed with any type of diabetes, including gestational diabetes
- HbA1c level outside healthy range (4% to 5.9%)
- Have an endocrine disease such as Cushing's syndrome
- Have food allergies, intolerances, or follow a vegan diet
- Taking medications that increase blood glucose (e.g., steroids, antipsychotics, statins)
- Taking medications that lower blood glucose (e.g., insulin, anti-hyperglycaemics, beta-blockers)
- Using medications affecting glucose regulation, appetite, digestion, or antibiotics
- Experienced a major medical or surgical event requiring hospitalization in the past 3 months
- Pregnant or lactating
- Participating in another clinical or supplementation trial or actively trying to lose weight
- Unable to comply with study procedures or safety guidelines
- Unable to provide informed consent
- Currently smoking
- Planning travel during the study period
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Aberdeen, Rowett Institute
Aberdeen, United Kingdom, AB25 2ZD
Actively Recruiting
Research Team
K
Karen Scott, PhD
CONTACT
G
Galiana Lo, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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