Actively Recruiting
Effect of Suicidality on Social Cognition
Led by Unity Health Toronto · Updated on 2024-05-09
150
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors. The prevalence of suicide attempt in Major Depressive Disorder (MDD) is about 20%. Risk for suicide attempt can be increased by many things such as negative life events, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors. In this study, the investigators will be collecting detailed information about participants' psychiatric history and depression symptoms, as well as brain scans. The goal is to use this information to help us determine what predicts suicide attempt history.
CONDITIONS
Official Title
Effect of Suicidality on Social Cognition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years old
- Able to give voluntary and informed consent
- Fluent in English
- Meet criteria for single or recurrent Major Depressive Disorder with current major depressive episode
- Moderate to severe depression with a Hamilton Depression Rating Scale score of 17 or higher
- No changes in psychotropic medication dose in the 4 weeks before screening
- Stable psychotherapy treatment for at least 3 months if applicable, with no planned changes
- Able to follow the study schedule
- History of suicide attempt or no lifetime suicide attempt, confirmed by interview
- For nondepressed participants: no current or past psychiatric diagnoses or suicidality
- For nondepressed participants: Hamilton Depression Rating Scale score below 8
- For nondepressed participants: no history of antidepressant use
You will not qualify if you...
- Pregnant or lactating
- Diagnosis of bipolar disorder with major depressive episodes
- Major medical conditions needing immediate treatment, cardiac pacemaker, or implanted medication pump
- Lifetime history of psychosis including schizophrenia or related disorders
- Drug abuse or dependence within the last 6 months, except caffeine and nicotine
- Contraindications for MRI such as metallic implants
- Significant neurological disorders or injuries including seizures (except ECT-induced), brain lesions, aneurysm, Parkinson's disease, Huntington's chorea, multiple sclerosis, dementia, or serious head trauma with loss of consciousness of 5 minutes or more
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Unity Health Toronto
Toronto, Ontario, Canada, M5B1M8
Actively Recruiting
Research Team
K
Katharine Dunlop, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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