Actively Recruiting
Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation A Double-blind Randomized Controlled Trial
Led by Beijing Friendship Hospital · Updated on 2026-05-20
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective, double-blind randomized controlled trial to compare the effects of two blood pressure management strategies during kidney transplantation. The study aims to evaluate whether using terlipressin alongside dobutamine during surgery improves postoperative graft function, reduces delayed graft function, and affects related complications compared to conventional dobutamine treatment alone. This trial addresses important questions about optimizing blood pressure control in patients undergoing kidney transplant surgery. Participants are randomly assigned to one of two groups: one receiving continuous dobutamine to manage blood pressure during surgery, and another receiving terlipressin before the graft circulation is established plus continuous dobutamine. Terlipressin is given intravenously as 1 mg combined with 100 ml sodium chloride when blood pressure is suboptimal and unresponsive to dobutamine or fluid resuscitation. Both groups receive treatment throughout the operation under close monitoring. During the study, researchers monitor delayed graft function within the first 7 days after surgery as the primary outcome. Participants are assessed for blood pressure stability, dosage of vasoactive drugs used, graft function, and any complications related to the treatments. The trial emphasizes careful intraoperative management and postoperative follow-up to gather detailed data on graft outcomes and safety. The study is sponsored by Beijing Friendship Hospital and plans to continue until June 2027.
CONDITIONS
Brief Title
Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with end-stage renal disease aged 18 years or above
You will not qualify if you...
- Simultaneous multiple organ transplantation
- Known allergy to study medication
- Known pregnancy status
- Cancellation of surgery due to grafts or personal reasons
- Persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications
- Any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - During the kidney transplantation surgery
Participants receive dopamine continuously during the operation, with dosage adjusted as needed. Those in the experimental group also receive terlipressin prior to graft circulation establishment if blood pressure is suboptimal and unresponsive to other measures.
1 intraoperative treatment period
Trial Site Locations
Total: 1 location
1
Beijing Friendship Hospital
Beijing, China
Actively Recruiting
Research Team
W
Wenhe Yang
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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