Actively Recruiting
The Effect of Time-Restricted Eating in Cardiometabolic Health
Led by Cambridge University Hospitals NHS Foundation Trust · Updated on 2025-11-24
100
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h TRE for 12 weeks, without a change in body weight, on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): 1) multi-organ insulin sensitivity; 2) 24 h metabolic homeostasis and diurnal rhythm; and 3) adipose tissue and skeletal muscle biology. The proposed studies will elucidate the cardiometabolic implications of TRE in people with obesity and prediabetes.
CONDITIONS
Official Title
The Effect of Time-Restricted Eating in Cardiometabolic Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be able to provide voluntary informed consent and follow study instructions
- Aged 25 to 75 years
- Men and women
- Body mass index between 27 and 45 kg/m2
- Fasting plasma glucose 5.6-6.9 mmol/L, or 2-hour oral glucose tolerance test plasma glucose 7.8-11.1 mmol/L, or hemoglobin A1C 39-46 mmol/mol, or HOMA-IR score ≥2.73
- Habitual eating period of 13 hours or more per day by self-report
You will not qualify if you...
- Shift workers
- Fasting more than 12 hours per day more than once a week
- Vegan diet
- Eating no food after about 6:00 PM more than once a week
- Habitually waking before about 4:00 AM and sleeping before about 9:00 PM
- Unstable weight with more than 5% change in last 2 months
- Clinical diagnosis of type 1 or 2 diabetes
- Clinical diagnosis of sleep disorder
- Clinical diagnosis of eating disorder
- Clinical diagnosis of cancer within last 5 years
- Conditions preventing completion of all testing procedures
- Use of medications affecting study outcomes or increasing risk that cannot be stopped temporarily
- Smoking or illegal drug use
- Pregnant or lactating
- Gastrointestinal or bariatric surgery (except gallbladder removal or appendix removal)
- Presence of electromedical devices
- Prisoners
- Alcohol abuse
AI-Screening
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Trial Site Locations
Total: 1 location
1
Cambridge Clinical Research Center
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
Research Team
M
Maria Chondronikola
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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