Comparing Topical Bromelain and Corticosteroids for Treating Oral Lichen Planus in a Randomized Clinical Trial

What this Trial Is About

Researchers are studying the effects of topical bromelain, a natural enzyme from pineapples known for its anti-inflammatory and wound-healing abilities, in treating Oral Lichen Planus OLP. This phase 2 randomized clinical trial compares bromelain with the standard corticosteroid treatment and a combination of both to evaluate their effectiveness and safety in managing OLP symptoms. Participants are divided into three groups to receive different treatments one group applies topical bromelain in orabase, another uses 0.1% triamcinolone acetonide in orabase a corticosteroid, and the third group applies a combination of both formulations. All treatments are applied four times daily, with no additional topical medications allowed, over a period of four weeks. During the study, participants will be closely monitored with weekly assessments of clinical improvement and quality of life, and daily pain intensity tracking during the first week followed by weekly reviews for the remaining weeks. The trial aims to provide clinical evidence on the benefits and safety of bromelain compared to corticosteroids, with the lead sponsor being Cairo University.

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus