What is bromelain studying for oral lichen planus?

Bromelain is being studied to see how well it works for treating oral lichen planus, a condition causing painful mouth sores. The trial compares bromelain alone, a common corticosteroid treatment, and a combination of both to find potentially safer and effective options. Cairo University is sponsoring this research to improve care for people with this condition.

Who may be eligible for this oral lichen planus clinical trial?

Adults with symptomatic oral lichen planus who have no other visible oral lesions may be eligible. Participants should not have systemic diseases or recent treatments with steroids or oral topical medications. Both men and women can join if they agree to the study and provide consent. Please review eligibility criteria for more details.

Is there any cost to participate in this oral lichen planus clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. However, personal travel expenses and other costs may vary and are not guaranteed to be covered.

Actively Recruiting

Phase 2

All Genders

ID06981767

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus A Randomized Clinical Trial

Led by Cairo University · Updated on 2026-03-03

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying oral lichen planus OLP, a condition causing painful oral mucosal ulcers, to evaluate the effectiveness of bromelain, an enzyme from pineapples known for its anti-inflammatory and wound-healing effects. This trial aims to provide clinical evidence on bromelains potential as a safer and effective treatment option compared to traditional corticosteroids. It is a randomized, phase 2 clinical trial comparing different topical treatments for OLP. Participants are assigned to one of three groups one group receives topical bromelain in orabase, another receives 0.1 topical triamcinolone acetonide in orabase a corticosteroid, and the third group receives a combination of both bromelain and triamcinolone acetonide. All treatments are applied four times daily, and no additional topical medications are allowed during the study period. Participants will be monitored over four weeks with weekly assessments of clinical improvement. Pain intensity is tracked daily during the first week and then weekly for the remaining three weeks. Oral health-related quality of life is also evaluated at baseline and weekly. The study includes careful monitoring of symptoms and responses to treatment under triple masking conditions to ensure unbiased results.

CONDITIONS

Brief Title

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus

Who Can Participate

All Genders

Eligibility Criteria

You may qualify if you...

Patients suffering from symptomatic oral lichen planus (OLP)
Patients free from any visible oral lesions other than OLP
Patients who agree to take the supplied interventions
Patients who agree to participate in the study
Patients who will sign the informed consent

You will not qualify if you...

Patients with any systemic disease
Patients treated with systemic steroids, immunosuppressive drugs, or non-steroidal anti-inflammatory drugs within the last eight weeks
Patients treated with any oral topical medications within the last four weeks
Pregnant and lactating mothers

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