Actively Recruiting
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Led by Wright State University · Updated on 2024-04-24
24
Participants Needed
1
Research Sites
266 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.
CONDITIONS
Official Title
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female ages 18 and older
- Skin type must be "Fair", Fitzpatrick type I to III
- Physician's order to receive photodynamic therapy on face, scalp, or forearms
- Willing to participate and understand informed consent
- Willing to avoid excess sun exposure or tanning beds on treated areas
You will not qualify if you...
- Currently taking any tricyclic antidepressants (TCAs)
- Currently taking any selective serotonin reuptake inhibitors (SSRIs)
- Diagnosis of porphyria
- Large tattoos in the treated areas
- Pregnancy or nursing
- Taking oral or topical medications that could interfere with photodynamic therapy
- Active rashes in the treatment area
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wright State Physicians
Fairborn, Ohio, United States, 45324
Actively Recruiting
Research Team
M
Manager, Clinical Research Operations
CONTACT
R
Regulatory Specialist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here