Actively Recruiting
Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels
Led by Indiana University · Updated on 2026-03-06
30
Participants Needed
1
Research Sites
58 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out if investigators can stimulate the vagus nerve (a nerve in the body that runs from your brain to the large intestine), and influence insulin, C-peptide, and glucose levels. C-peptide is a substance that is created when insulin is produced and released into the body. The vagus nerve is a largely internal nerve that controls many bodily functions, including stomach function. Investigators hope that by stimulating the vagal nerve using the TeNS behind the ear, this stimulation can affect insulin levels, and this will help innovate treatment of patients with nausea, vomiting, and disordered stomach function, and patients with diabetes. Researchers hope to be able to measure the activity of the vagus nerve when it is stimulated in other ways. This could help investigators learn more about studying this nerve in the future.
CONDITIONS
Official Title
Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy Volunteers
- Aged 18-70
- Willing to have ECG electrodes placed on their neck and chest areas
- Willing to have electrodes placed in the external ear
- Willing to have an indwelling catheter placed to avoid multiple sticks for blood draw
You will not qualify if you...
- Unable to provide consent
- Diabetes diagnosis per patient report
- Known allergies to adhesive on electrode pads or bandages
- Having gastric motility issues as determined by the PI or clinical coordinator
- Taking medications that may affect gastric motility or cardiac variability (e.g. alpha or beta blockers for hypertension)
- Pregnant females
- Unwilling to have the taVNS device placed in their ear
- Unwilling to consent to a blood draw
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Indiana University Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
M
Maureen Schilling, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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